Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
White matter hyper intensity is a distinctive radiological feature in the elderly and is now considered to be associated with vascular dementia. Diffusion MRI is sensitive to white matter changes, and several dMRI parameters have proven useful at predicting the likelihood of developing dementia. Recent high profile studies have used dMRI to probe structural connectivity in patients with white matter hyperintensites. Reduced global efficiency at baseline was a good predictor of conversion to dementia over the follow up period. Animal models offer the opportunity to explore the mechanisms that may underpin these changes, though connectivity analysis is not yet as established in rodents as in humans. We have preliminary data that suggests there are structural connectivity impairments in a mouse model of brain hypoperfusion that recapitulates features of white matter damage. Recently, we have been trying to link these findings to functional information from rsfMRI to better understand network vulnerability to hypoperfusion.
