Chancellor’s Fellow, Centre for Integrative Physiology, University of Edinburgh
Dr Osterweil’s research questions are being investigated in multiple neural circuits using biochemical, electrophysiological and systems-level approaches.
Current projects include:
Determining the role of NMDA receptors in local protein synthesis
Tracking cell type specific changes in translation during plasticity using cell type-specific Translating Ribosome Affinity Purification and RNA-seq
Investigating the translation control pathways linked to different postsynaptic receptors
Exploring the role of protein turnover in synaptic plasticity
Dr Osterweil’s group are studying these basic biological questions using animal models of fragile X syndrome, Tuberous Sclerosis, and other neurodevelopmental disorders. It is their belief that identifying the mechanisms that go awry in these models will simultaneously address fundamental questions of synaptic function, and provide a better understanding of autism and ID.