Cell type-specific translation profiling in fragile X
Chancellor’s Fellow, Centre for Integrative Physiology, University of Edinburgh
Dr Osterweil’s research questions are being investigated in multiple neural circuits using biochemical, electrophysiological and systems-level approaches.
Current projects include:
Determining the role of NMDA receptors in local protein synthesis
Tracking cell type specific changes in translation during plasticity using cell type-specific Translating Ribosome Affinity Purification and RNA-seq
Investigating the translation control pathways linked to different postsynaptic receptors
Exploring the role of protein turnover in synaptic plasticity
Dr Osterweil’s group are studying these basic biological questions using animal models of fragile X syndrome, Tuberous Sclerosis, and other neurodevelopmental disorders. It is their belief that identifying the mechanisms that go awry in these models will simultaneously address fundamental questions of synaptic function, and provide a better understanding of autism and ID.
Date:
23 January 2018, 12:00 (Tuesday, 2nd week, Hilary 2018)
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Small Lecture Theatre - 2nd floor
Speaker:
Dr Emily Osterweil (University of Edinburgh)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Melanie Witt (University of Oxford, Department of Earth Sciences, Department of Physiology Anatomy and Genetics)
Organiser contact email address:
opdc.administrator@dpag.ox.ac.uk
Part of:
OPDC Seminar Series (DPAG)
Topics:
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Melanie Witt
