Dr Ilaria Ferlenghi "An Integrated structural and digital approach for vaccine identification and pathogenesis insight"
The selection in silico of vaccine candidates by Reverse Vaccinology can be challenged by: sequence variability of the pathogens, the immune evasion strategies adopted by the pathogens, the low abundance of surface antigens and eventually their low stability once expressed as recombinant antigens. These challenges can be faced with a deep knowledge of the three-dimensional structure of the candidates. The advances in cryo-EM together with well-set X-ray crystallography and HDx-MS allowed recently the structural characterization of a huge amount of new proteins. The use of 3D protein structures similarity is a key tool in the highly specific antigen identification. We generate and compare 3D protein structure by the Structure Similarity Algorithm GEMINI running in a dedicated freely available GSK repository that contains internally generated structures as well as publicly available structure related databases and literature data.
Date: 17 October 2019, 11:00 (Thursday, 1st week, Michaelmas 2019)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Meeting room A
Speakers: Speaker to be announced
Organising department: Wellcome Trust Centre for Human Genetics
Organiser: Agata Krupa (Wellcome Centre for Human Genetics, University of Oxford)
Organiser contact email address: strubiadmin@strubi.ox.ac.uk
Host: Prof David Stuart (University of Oxford)
Part of: Strubi seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Agata Krupa