Global Biochemical Profiling for Problem Solving in Biology and Disease
Towards New Antibiotics – Targeting Penicillin Binding Proteins
The lecture will begin by giving some thoughts on possible reasons as to why β-lactams remain the most important antibacterials after more than 70 years of use. Mechanisms of resistance to the β-lactams will be described, focussing on the β-lactamases. A review of attempts to develop non β-lactams targeting the penicillin binding protein (PBP) targets of β-lactams and β-lactamases will be given. Work aimed at the development of single compounds targeting PBPs and both metallo and serine β-lactamases will be described.
Date:
20 September 2017, 13:00 (Wednesday, -2nd week, Michaelmas 2017)
Venue:
NDM Building, Headington OX3 7FZ
Venue Details:
TDI Basement seminar room
Speaker:
Prof Chris Schofield (Head of Organic Chemistry, Univ Oxford)
Organising department:
Structural Genomics Consortium
Organiser:
Natsumi Astley (University of Oxford )
Organiser contact email address:
natsumi.astley@sgc.ox.ac.uk
Host:
Prof Frank von Delft (SGC, University of Oxford)
Part of:
CMD Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Natsumi Astley
