OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
CD8+ T cells can recognise and kill virus-infected cells and cancer cells. Understanding how they first recognise antigen, then proliferate and differentiate, is crucial to improving the design of vaccines and immunotherapy for viral infections and cancer. The immunology canon teaches us that a subset of dendritic cells (CLEC9A+ XCR1+ “DC1”) initiates CD8+ T cell responses in lymph nodes. However single cell and spatial data from human lymphoid tissue suggest DC1 are unlikely to fulfil this role in humans. What are the alternative scenarios for “priming” human CD8+ T cells – and what are the implications for immune therapy?
