Oxford Events, the new replacement for OxTalks, will launch on 16th March. The two-week OxTalks freeze period starts on Monday 2nd March. During this time, there will be no facility to publish or edit events. The existing OxTalks site will remain available to view during this period. Once Oxford Events launches, you will need a Halo login to submit events. Full details are available on the Staff Gateway.
My lab is interested in novel antiviral drugs that can be used to combat important viral diseases and as chemical tools to address basic research questions. We are investigating HIV-1 maturation inhibitors, which have a novel mechanism of action as they target the HIV-1 Gag protein. In recent work we have used an analogue series of the maturation inhibitor PF-46396 to dissect structure-activity relationships. A second major research interest is to determine if fundamental knowledge about viral interferon antagonist function can be leveraged into translational research to impact the treatment of viral diseases. To do this we have developed a novel cell-based screening platform that allows us to target a viral interferon antagonist of choice. We have successfully used this assay to identify hit molecules that specifically inhibit Respiratory Syncytial Virus (RSV) NS2.
