OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
My lab is interested in novel antiviral drugs that can be used to combat important viral diseases and as chemical tools to address basic research questions. We are investigating HIV-1 maturation inhibitors, which have a novel mechanism of action as they target the HIV-1 Gag protein. In recent work we have used an analogue series of the maturation inhibitor PF-46396 to dissect structure-activity relationships. A second major research interest is to determine if fundamental knowledge about viral interferon antagonist function can be leveraged into translational research to impact the treatment of viral diseases. To do this we have developed a novel cell-based screening platform that allows us to target a viral interferon antagonist of choice. We have successfully used this assay to identify hit molecules that specifically inhibit Respiratory Syncytial Virus (RSV) NS2.
