New genomic technologies to deconstruct and control cell identity
A mechanistic understanding of how cell identity is established and maintained is fundamental to the precise engineering of cell fate. Here, I will present new genomic technologies developed by my lab to permit single-cell lineage tracing throughout reprogram-ming, accompanied by recording of TF-binding and chromatin accessibility profiling. Integrating this information using our unique computational tools for interrogating gene regulatory networks delivers a systems-level understanding of how cell identity can be manipulated via lineage reprogramming. We also apply these methods to understand how cell identity is naturally programmed during differentiation and development. The deconstruction of cell identity via these approaches supports precision engineering of cell fate.
Date:
31 March 2023, 15:00 (Friday, 11th week, Hilary 2023)
Venue:
IMS-Tetsuya Nakamura Building, Roosevelt Dr, Headington OX3 7TY
Venue Details:
Seminar Rooms 1&2
Speaker:
Associate Professor Samantha Morris (Washington University School of Medicine)
Organisers:
Dr Thomas Roberts (Department of Paediatrics),
Dr Rebecca Berrens (Department of Paediatrics),
Dr Filipa Simões (DPAG, IDRM, University of Oxford),
Associate Professor Carlo Rinaldi (University of Oxford, MDUK Oxford Neuromuscular Centre),
Dr Oliver Stone (University of Oxford, Department of Physiology, Anatomy and Genetics (DPAG))
Host:
Dr Filipa Simões (DPAG, IDRM, University of Oxford)
Part of:
IDRM Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Rufina Kaloyanova
