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Lipid Deuteration against Neurodegeneration
Polyunsaturated fatty acids (PUFAs) are part of lipid bilayer membranes that are vital for neuronal and retinal performance. However, their structure makes PUFAs vulnerable to the chain reaction of lipid peroxidation, which cannot be controlled by antioxidants. Lipid peroxidation damages membranes and produces toxic secondary products, which play a major role in the aetiology of many neurological and retinal diseases, as well as in ageing.
A novel approach will be discussed that stabilizes PUFAs against the peroxidation chain reaction, without altering their chemical identity, by means of deuterating the oxidation-prone sites. This approach is currently undergoing several clinical trials.
Date:
7 January 2020, 16:00
Venue:
Tinsley Building, Mansfield Road, Oxford
Speakers:
Dr Mikhail Shchepinov (Chief Scientific Officer, Retrotope Inc),
Mikhail Shchepinov (Retrotope Inc)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Fiona Woods (University of Oxford, Department of Physiology Anatomy and Genetics, Centre for Neural Circuits and Behaviour)
Organiser contact email address:
fiona.woods@cncb.ox.ac.uk
Part of:
CNCB Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Fiona Woods
