Enhancing Suicide Risk Prediction With Polygenic Scores in Psychiatric Emergency Settings: Prospective Study
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Despite growing interest in the clinical translation of polygenic risk scores (PRSs), it remains uncertain to what extent genomic information can enhance the prediction of psychiatric outcomes beyond the data collected during clinical visits alone.
This study aimed to assess the clinical utility of incorporating PRSs into a suicide risk prediction model trained on electronic health records (EHRs) and patient-reported surveys among patients admitted to the emergency department.
Study participants were recruited from the psychiatric emergency department at Massachusetts General Hospital. There were 333 adult patients of European ancestry who had high-quality genotype data available through their participation in the Mass General Brigham Biobank. Multiple neuropsychiatric PRSs were added to a previously validated suicide prediction model in a prospective cohort enrolled between February 4, 2015, and March 13, 2017. Data analysis was performed from July 11, 2022, to August 31, 2023. Suicide attempt was defined using diagnostic codes from longitudinal EHRs combined with 6-month follow-up surveys. The clinical risk score for suicide attempt was calculated from an ensemble model trained using an EHR-based suicide risk score and a brief survey, and it was subsequently used to define the baseline model. We generated PRSs for depression, bipolar disorder, schizophrenia, suicide attempt, and externalizing traits using a Bayesian polygenic scoring method for European ancestry participants.
Date:
4 March 2025, 15:00 (Tuesday, 7th week, Hilary 2025)
Venue:
https://zoom.us/j/92860307789?pwd=iAdkC3QG1wQ8yvbuOBFTibGofmszPY.1
Speaker:
Professor Jordan Smoller (Harvard Medical School)
Organising department:
Department of Psychiatry
Organiser:
Dr Andrey Kormilitzin (University of Oxford)
Organiser contact email address:
andrey.kormilitzin@psych.ox.ac.uk
Host:
Dr Andrey Kormilitzin (University of Oxford)
Part of:
Artificial Intelligence for Mental Health Seminar Series
Booking required?:
Not required
Booking url:
https://web.maillist.ox.ac.uk/ox/info/ai4mch
Booking email:
andrey.kormilitzin@psych.ox.ac.uk
Audience:
Public
Editor:
Andrey Kormilitzin