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Recent advances in Cryo-EM structure determination
Cryo-EM single particle analysis is undergoing rapid changes. In this
talk, I will discuss how developments in sensitive and fast direct
electron detectors yield movies with relatively high signal-to-noise
ratios, and how new image processing techniques to deal with
beam-induced motions and structurally heterogeneous samples are now
yielding near-atomic resolution reconstructions for a wide range of
specimens. I will illustrate the potentials of these methods by
highlighting our recent results on various structures of human
gamma-secretase, the intramembrane protease complex responsible for
cleavage of amyloid precursor protein.
Date:
13 November 2015, 11:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting Room B
Speaker:
Dr Sjors Scheres (MRC Lab of Molecular Biology, Cambridge )
Organising department:
Division of Structural Biology
Organiser:
Eleanor Martin (Wellcome Trust Centre for Human Genetics)
Organiser contact email address:
jones-pa@strubi.ox.ac.uk
Hosts:
Prof E.Yvonne Jones (University of Oxford),
Prof David Stuart (University of Oxford)
Part of:
Strubi seminars
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Eleanor Martin,
Agata Krupa
