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OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
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The genetic basis of infertility and reproductive hormones across the allele frequency spectrum
Abstract:
Genome-wide association studies (GWASs) may help inform treatments for infertility, which is a common, complex condition with an unknown cause in many cases. We performed GWAS meta-analyses across six cohorts for male and female infertility (in up to 41,200 cases and 687,005 controls), as well as sex-specific reproductive hormones, to identify 21 genetic risk loci for infertility and over 269 loci for hormone levels. We also performed exome sequencing analyses in the UK Biobank to query rare variant contributions to infertility and reproductive hormone levels. We assessed evidence for overlap between the genetic architecture of infertility, hormones, and other female reproductive conditions such as endometriosis and PCOS using a variety of statistical tools. In this talk, I will provide a comprehensive view of the genetic architecture of infertility across multiple diagnostic criteria in men and women, and characterise its relationship to other health conditions.
Date:
9 July 2024, 13:00
Venue:
This event is hybrid
Speaker:
Samvida Venkatesh (University of Oxford)
Organising department:
Nuffield Department of Women's and Reproductive Health
Organisers:
Dr Lydia Coxon (NDWRH, University of Oxford),
Dr Mike Suttie (University of Oxford)
Organiser contact email address:
seminars@wrh.ox.ac.uk
Booking required?:
Recommended
Booking email:
seminars@wrh.ox.ac.uk
Audience:
Members of the University only
Editor:
Isobel Way
