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Neuroimmunometabolism - by Dr Ana Domingos, University of Oxford
For joining details please see the Society’s FB events page: fb.me/e/15v36zbce
The Domingos laboratory researches neuroimmune mechanisms underlying obesity. They discovered neuro-adipose junctions, between white adipocytes and sympathetic neurons, that are necessary and sufficient for fat mass reduction via norepinephrine (NE) signalling. Moreover, they discovered Sympathetic neuron-
Associated Macrophages (SAMs) that import and metabolize NE. Abrogation of SAM function promotes long-term amelioration of obesity independently of food intake. These findings inspired the development of a new class of anti-obesity compounds named sympathofacilitators, which do not enter the brain, nor have the typical cardiovascular side effects of centrally acting sympathomimetic drugs. Sympathofacilitator drugs act as an energy sink by coupling thermogenesis to active heat dissipation.
Ana Domingos is a member of the advisory board of Cell Metabolism and is a member of the board of reviewing editors at eLife. Her lab has been funded by HHMI, Wellcome Trust, ERC, HFSP, EMBO among other.
Date:
11 March 2021, 18:30
Venue:
virtual livestream
Speaker:
Professor Ana Domingos (University of Oxford, DPAG)
Organiser:
Oxford University Scientific Society (University of Oxford)
Organiser contact email address:
scientific.society@studentclubs.ox.ac.uk
Booking required?:
Not required
Cost:
free
Audience:
Public
Editor:
Luna Li
