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Impaired path-integration is associated with early Tau pathology in the entorhinal-hippocampal neural networks
Recent studies in individuals at increased risk of Alzheimer’s disease suggest that impairments in path integration may represent one of the earliest cognitive deficits, emerging before broader memory decline. The medial entorhinal cortex and hippocampus are central to spatial memory and navigation, with grid cells playing a crucial role in path integration. We therefore hypothesised that dysfunction within medial entorhinal–hippocampal circuits contributes to the early decline in path integration, and that Tau hyperphosphorylation in these areas could be among the earliest molecular events driving these abnormalities. To test this hypothesis, we employed a novel early-stage (pre-tangle) Tauopathy mouse model (S305N KI) to determine whether Tau hyperphosphorylation can recapitulate key path-integration deficits seen in humans and to identify the associated alterations in cellular and network activity underlying these early impairments.
Date:
3 December 2025, 15:00
Venue:
Pharmacology, off Mansfield Road OX1 3QT
Venue Details:
Pharmacology Lecture Theatre
Speaker:
Dr. Julija Krupic (University College London)
Organising department:
MRC Brain Network Dynamics Unit
Host:
Professor David Dupret (Nuffield Department of Clinical Neurosciences, University of Oxford)
Part of:
Brain Network Dynamics Seminar Series
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Nima Mirkhani
