Regulation of microtubule organisation and dynamics: seeing proteins and drugs in action
This talk has been cancelled. Apologies for any inconvenience caused
Microtubules are dynamic cytoskeletal filaments that control different aspects of cell architecture. Microtubules are intrinsically asymmetric polymers, with fast-growing plus ends, which in cells serve as major sites of microtubule assembly and disassembly, and slow-growing minus ends, which are often stabilized and attached to different cellular structures. In my lab, we use in vitro assays combined with single molecule imaging to dissect how the proteins that bind to microtubule plus- and minus ends control microtubule nucleation and dynamics. In parallel, we employ live cell imaging to study how microtubules contribute to cell polarity, migration, division and differentiation. The combination of in vitro reconstitution assays with experiments in cells allows us to decipher how the specific molecular properties of microtubule regulators contribute to cellular function.
Date: 24 April 2020, 14:00 (Friday, 0th week, Trinity 2020)
Venue: Medical Sciences Teaching Centre, off South Parks Road OX1 3PL
Venue Details: Lecture Theatre
Speaker: Professor Anna Akhmanova (Utrecht University)
Organising department: Sir William Dunn School of Pathology
Organiser: Dawn Gibbons (Sir William Dunn School of Pathology )
Organiser contact email address: dawn.gibbons@path.ox.ac.uk
Part of: Dunn School of Pathology Departmental Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Dawn Gibbons