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Abstract: The Convention of Biological Diversity Conference of the Parties will soon negotiate the post-2020 global biodiversity framework, perhaps our last best chance for a sustainable future in which people and the planet can thrive. After briefly outlining how much trouble we’re in, I will argue that there is no single target that can safeguard biodiversity, that only indicators that can be modelled will help us find sustainable pathways, and that the main role of monitoring biodiversity is to improve models.