Exploring the dynamics of DNA methylation and interaction with genotype in response to inflammatory stimuli
Chronic inflammation is implicated in the pathogenesis of the majority of common diseases including cancer. Understanding the molecular determinants of the inflammatory response is therefore of high importance to human health. DNA methylation at cytosine:guanine dinucleotides (CpGs) is a key epigenetic mark that elicits pronounced transcriptional consequences. How DNA methylation changes over the inflammatory response, and the influence of genetic variation on this is relatively unexplored.
I will present novel data from a project to explore variation in monocyte DNA methylation during exposure to divergent inflammatory stimuli with reference to genotype. I will also describe an ongoing project whereby these findings are being translated to cancer in an effort to dissect the epigenetic impact of malignancy on circulating immune subsets.
18 January 2018, 11:00 (Thursday, 1st week, Hilary 2018)
NDM Building, Headington OX3 7FZ
Basement seminar room, TDI
Benjamin Fairfax (Department of Oncology, University of Oxford)
Ludwig Institute for Cancer Research, Oxford Branch
Christina Woodward (Oxford Ludwig Institute, Nuffield Department of Medicine, University of Oxford)
Organiser contact email address:
Prof Xin Lu (Ludwig Cancer Research, Oxford Branch)
Ludwig Institute Seminar Series
Members of the University only