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Pivotal roles for type 2 immunity in epithelial immune surveillance
A high number of lymphocytes constitutively associate with epithelial tissues and these are called intraepithelial lymphocytes (IELs). IELs are not restricted to classical MHC and often express T cells receptors (TCRs). In this talk, I will discuss the capacity of TCR+ IELs in the skin to directly sense the health status of epithelial cells and to initiate a multifaceted response to promote homeostasis and tissue repair.
By a variety of means IELs cross-communicate with epithelial cells to regulate their proliferation, differentiation, transit time through the epidermis and even DNA repair. I will particularly focus on the importance of type 2 immunity in mediating immune-surveillance and will address how IL-33 contributes to skin homeostasis via regulation of tissue-resident Treg.
Overall, the talk will provide novel information on the versatile regulation of epithelial cells by type 2 immunity which ultimately strengthens the epithelial barrier and decreases susceptibility to damage and cancer development.
Date:
12 March 2024, 9:30
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Room A+B
Speaker:
Professor Jessica Strid (Imperial College London)
Organisers:
Dr Ricardo Fernandes (CAMS Oxford Institute),
Dr Dannielle Wellington (CAMS Oxford Institute),
Mimie Szyk (CAMS Oxford Institute)
Part of:
CAMS Oxford Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Mimie Szyk
