Silence Therapeutics - When less is more: A new twist to GalNAc-conjugate siRNA for treatment of liver-related disorders
Lunch is provided. Please register. 1:1 meetings available. Suitable for anyone with an interest in the topic eg PhD to Professor.
Silence Therapeutics explores different options for fine tuning of GalNAc-conjugated siRNA design. Areas of special interest include siRNA modification patterns, end stabilisation, linker chemistry, and the number and location of GalNAc units. One in house discovery is that two single GalNAc units, positioned a distance apart on the sense strand, demonstrated increased activity and duration of action in wild type mice for a tool compound targeting TTR, compared to a “traditional” GalNAc triantennary design of the same siRNA sequence. At day 27 after single injection the novel design resulted in 85% reduction of target serum protein, compared to 36% reduction by equimolar amount of the control molecule. This design, as part of a molecule design toolbox, is being validated for novel siRNA GalNAc conjugates that may eventually be used as therapeutic options in liver-centric disease. We are also optimistic that the same design/synthesis principle will be useful when designing siRNA conjugates for extra-hepatic purposes.
Date: 4 December 2019, 12:00 (Wednesday, 8th week, Michaelmas 2019)
Venue: Innovation Building
Venue Details: BioEscalator, ground floor.
Speakers: Speaker to be announced
Organising department: Medical Sciences Division
Organiser contact email address: siobhan.dennis@medsci.ox.ac.uk
Part of: Industry Insights Seminar Series
Topics:
Booking required?: Required
Booking url: https://www.eventbrite.co.uk/e/when-less-is-more-a-new-twist-to-galnac-conjugated-sirna-for-treatment-of-liver-related-disorders-tickets-77098031287
Cost: free
Audience: Public
Editor: Siobhan Dennis