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Genome Editing of Stem Cells: Moving Towards the Clinic
Genome editing provides a mechanism to precisely change the DNA sequence of cells with single nucleotide precision. We have developed a highly efficient platform to modify multiple types of human stem cells, including hematopoietic stem cells and pluripotent stem cells, with high efficiency using a combination of CRISPR/Cas9 and AAV6. I will discuss our progress in applying this platform to several different genetic diseases of the blood and immune system including sickle cell disease and severe combined immunodeficiency. In addition, I will discuss our optimized protocols to generate precisely modified human pluritpotent stem cells.
Date:
2 July 2018, 11:00
Venue:
MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details:
Seminar Room
Speaker:
Dr. Matthew Porteus (Stanford University, School of Medicine)
Organising department:
MRC Weatherall Institute of Molecular Medicine
Organiser:
Sabrina Harris (Department of Paediatrics, University of Oxford)
Organiser contact email address:
sabrina.harris@paediatrics.ox.ac.uk
Host:
Georg Holländer (Department of Paediatrics, University of Oxford)
Part of:
WIMM Occasional Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sarah Butler
