Functional genomics approaches to find novel disease genes

Greg completed his PhD in human immunology at the University of Calgary, Canada and then a post doc in functional genomics at IMBA in Vienna Austria. Since 2010 Greg has run a functional genomics lab in Sydney Australia, first at the Garvan Institute, and more recently at the Charles Perkins Centre at the University of Sydney. His lab uses human genomics data (GWAS or EXOME) to focus high throughput functional validation of candidate disease genes in cell culture or fruit flies. Currently the lab is investigating conserved regulators of heart function, longevity, obesity, neurodegeneration, pancreatic cancer, kidney function and chronic pain. For pain, his team has defined the whole genome requirements for acute heat pain perception in the fly, and are currently using multiple novel high-throughput chronic pain paradigms.