On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
Mutations in innate immune genes can cause inherited inflammatory diseases (autoinflammatory diseases), which are the focus for the Masters laboratory. This work involves identifying and validating the functional significance of novel genetic variants, and the pathways in which they fall. One particular pathway of interest is the inflammasome, with recent findings showing how mutations in the Pyrin inflammasome cause Pyrin Associated Autoinflammation with Neutrophilic Dermatosis (PAAND). Related work studied mutations in the NLRP1 and NLRP3 inflammasomes, and observations from these rare diseases was extended to the analysis of common diseases such as obesity/type 2 diabetes and inflammatory bowel disease. This work provides therapeutic outcomes for patients with severe autoinflammatory disease, and shows how innate immune pathways influence common inflammatory diseases.
