Insights into malaria parasite protein translation machinery and implications for drug discovery
Over the past 7 years, our laboratory has dissected malaria parasite proteins that are involved in protein translation. Our work has highlighted the importance of parasitic tRNA synthetases as new druggable targets. We will discuss how the malaria parasite is able to utilise its resources to achieve protein translation in three separate cellular compartments. We will also discuss complex structures of two tRNA synthetases with natural product compounds, and analyse bases for development of drug resistance.
Date:
14 January 2016, 15:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting Room A
Speaker:
Amit Sharma (International Centre for Genetic Engineering and Biotechnology )
Organising department:
Division of Structural Biology
Organiser:
Prof David Stuart (University of Oxford)
Organiser contact email address:
strubi-pa@strubi.ox.ac.uk
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Agata Krupa
