The Epigenetic Landscape of T cell Exhaustion
Exhausted T cells lose the ability to proliferate or secrete effector cytokines, express multiple inhibitory receptors (such as PD-1) and are defined by a distinct, abnormal program of gene expression. The focus of the Haining lab is on the transcriptional and epigenetic regulation of the exhausted T cell state. We have found that the differentiation of exhausted T cells occurs with state-specific regulation of genes critical to their dysfunction, offering targets for genome editing that could alter gene expression preferentially in exhausted CD8+ T cells.
29 September 2016, 12:00 (Thursday, -1st week, Michaelmas 2016)
Medawar Building, off South Parks Road OX1 3SY
Level 30 conference room
W. Nicholas Haining (Department of Pediatric Oncology, Dana-Farber Cancer Institute Harvard Medical School Broad Institute of Harvard and MIT)
Prof. Paul Klenerman (Peter Medawar Building, NDM, Oxford)
Members of the University only