Neural Plasticity from Synapse to Cognition
The cognitive functions of the brain such as learning and memory depend on the ability of neural circuits to change their properties of signal processing in response to prior use. Many of these use-dependent changes (“plasticity”) occur at synapses where signals are transmitted between neurons. Depending on the pattern of neuronal activities, repetitive synaptic transmission could cause long-term potentiation (LTP) or long-term depression (LTD) of the synapse in its efficacy for future transmission. I will summarize our studies on how the timing of neuronal activities (spikes) in the pre- and post-synaptic neurons determines whether a synapse undergoes LTP or LTD, a phenomenon known as “Spike Timing-Dependent Plasticity” (STDP), and how STDP may provide the mechanism for coding and storing the information on the temporal sequence and interval of sensory signals, two key elements of episodic memories. I will also discuss in general the idea that neural plasticity is the main factor that shapes the development of neural circuits, and that neural plasticity offers the potential for functional recovery from injuries and diseases of the adult brain. Finally, to argue that higher cognitive functions in humans such self-awareness may originate from experience-dependent neural plasticity, I will present our recent finding showing that mirror self-recognition, a cognitive function known to be limited only to humans and great apes, could be acquired by rhesus monkeys following training of visual-somatosensory or visual-proprioceptive association.
Date: 17 April 2018, 16:00 (Tuesday, 0th week, Trinity 2018)
Venue: Sherrington Building, off Parks Road OX1 3PT
Venue Details: Large Lecture Theatre
Speaker: Professor Mu-Ming Poo (Institute of Neuroscience in Shanghai)
Organising department: Department of Physiology, Anatomy and Genetics (DPAG)
Organiser: Sally Collins (University of Oxford)
Organiser contact email address:
Host: Professor Kristine Krug (DPAG, University of Oxford)
Part of: The Charles Sherrington Lecture Series
Booking required?: Not required
Audience: Members of the University only
Editor: Sally Collins