Multi-scale modeling of chromosomal DNA from the base pair to the genome
The organization and dynamics of chromosomal DNA play a pivotal role in a range of biological processes, including gene regulation, homologous recombination, replication, and segregation. Establishing a quantitative theoretical model of DNA organization and dynamics would be valuable in bridging the gap between the molecular-level packaging of DNA and genome-scale chromosomal processes. Our research group utilizes analytical theory and computational modeling to establish a predictive theoretical model of chromosomal organization and dynamics. In this talk, I will discuss our efforts to develop multi-scale polymer models of chromosomal DNA that are both sufficiently detailed to address specific protein-DNA interactions while capturing experimentally relevant time scales
Date: 2 September 2016, 11:00 (Friday, 19th week, Trinity 2016)
Venue: Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details: Main Seminar Room
Speaker: Dr Andrew Spakowitz (Stanford University)
Organising department: Department of Biochemistry
Organiser: Professor David Sherratt (University of Oxford)
Organiser contact email address: david.sherratt@bioch.ox.ac.uk
Part of: Biochemistry Department Seminar
Booking required?: Not required
Audience: Members of the University only
Editor: Carla Bramble