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Multi-scale modeling of chromosomal DNA from the base pair to the genome
The organization and dynamics of chromosomal DNA play a pivotal role in a range of biological processes, including gene regulation, homologous recombination, replication, and segregation. Establishing a quantitative theoretical model of DNA organization and dynamics would be valuable in bridging the gap between the molecular-level packaging of DNA and genome-scale chromosomal processes. Our research group utilizes analytical theory and computational modeling to establish a predictive theoretical model of chromosomal organization and dynamics. In this talk, I will discuss our efforts to develop multi-scale polymer models of chromosomal DNA that are both sufficiently detailed to address specific protein-DNA interactions while capturing experimentally relevant time scales
Date:
2 September 2016, 11:00
Venue:
Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details:
Main Seminar Room
Speaker:
Dr Andrew Spakowitz (Stanford University)
Organising department:
Department of Biochemistry
Organiser:
Professor David Sherratt (University of Oxford)
Organiser contact email address:
david.sherratt@bioch.ox.ac.uk
Part of:
Biochemistry Department Seminar
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Carla Bramble
