The way forward to HIV vaccine development

Bart Haynes is a leader in HIV Vaccine development and heads the NIH Center for HIV/AIDS Vaccine Development. He has made many seminal contributions on understanding how HIV Envelope evolves during infection, selected by a mutating antibody response. He has unravelled how broadly neutralizing antibodies develop, how they bind to the Envelope and what regulates these immune responses. His programme aims to get Envelope based vaccines that stimulate broadly neutralizing antibodies into clinical trial within five years.

Liao HX, …….. Mascola, J.R., Haynes BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496(7446):469-76
Bonsignori M, …….., Kwong PD, Haynes BF. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell. 2016;165(2):449-63.