An expanding job description for the Zinc finger transcriptional repressor Blimp1/Prdm1 in the developing mouse embryo
The zinc finger transcriptional repressor B-lymphocyte-induced maturation protein 1 (Blimp1), encoded by the Prdm1 gene, originally cloned as negative regulator of β-interferon gene expression and subsequently identified as a master regulator of plasma cell terminal differentiation, governs cell fate decisions in the developing embryo and adult tissues. In the early embryo, Blimp1 is required to specify the primordial germ cell lineage, and embryos die at midgestation due to an essential requirement in the placenta. Using conditional deletion experiments we have found that Blimp1 activities are essential for morphogenesis of the pharynx, forelimbs and heart. In addition Blimp1 regulates the developmental switch responsible for post-natal reprogramming of the intestinal epithelium. Most recently we have found that Blimp1 identifies a rare population of luminal progenitors in the mammary gland that are essential for morphogenesis and organ homeostasis.
Date: 12 January 2017, 11:00 (Thursday, 0th week, Hilary 2017)
Venue: Old Road Campus Research Building, Headington OX3 7DQ
Venue Details: Ludwig Seminar Room, basement ORCRB
Speaker: Professor Elizabeth Robertson (University of Oxford)
Organising department: Ludwig Institute for Cancer Research, Oxford Branch
Organisers: Mary Muers (Oxford Ludwig Institute, NDM Experimental Medicine), Alexandra Ward (University of Oxford, Oxford Ludwig Institute, NDM Experimental Medicine), Christina Woodward (Oxford Ludwig Institute, Nuffield Department of Medicine, University of Oxford)
Organiser contact email address: christina.woodward@ludwig.ox.ac.uk
Host: Dr Sarah De Val (LICR, University of Oxford)
Part of: Ludwig Institute Seminar Series
Topics: Developmental biology
Booking required?: Not required
Audience: Members of the University only
Editors: Mary Muers, Christina Woodward