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SIR WILFRID LE GROS CLARK PRIZE LECTURE 2025: Phase separation in cell physiology and disease
Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that one common mechanism for such biochemical organization is phase separation of disordered proteins to form compartments with liquid properties. These compartments can subsequently harden to form compartments with new material properties such as gels and glasses. These compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. I will discuss potential roles of phase separation in organization and robustness of cellular biochemistry and how they fail in disease.
Date:
6 March 2025, 16:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Blakemore Lecture Theatre
Speaker:
Professor Tony Hyman (Max Planck Institute of Molecular Cell Biology and Genetics)
Organising department:
Department of Physiology, Anatomy and Genetics (DPAG)
Organiser:
Professor David Paterson (DPAG, University of Oxford)
Organiser contact email address:
events@dpag.ox.ac.uk
Host:
Professor David Paterson (DPAG, University of Oxford)
Part of:
DPAG Prize Lectures
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Hannah Simm
