OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Understanding MAIT cells: pathogenic role in gastritis
Mucosal Associated Innate T (MAIT) cells are innate like T lymphocytes that express a semi-invariant TCR and are restricted by the non-classical MHC class I-related molecule, MR1. These cells are predominantly found at mucosal surfaces and are activated by a novel class of antigens, intermediates of the riboflavin synthesis pathway that are produced by certain class of bacteria and yeasts.
We have examined whether MAIT cells play a role in the pathology of chronic H. pylori infection. We have recently developed highly specific MR1 tetramers that have been used to detect and characterize MAIT cells in mice. Our studies show that MAIT cells play a key role in the regulation of gastric inflammation in H. pylori infection. Using a mouse model that first enriches MAIT cells in the lung, we show repopulation of MAIT cells to other mucosal sites including the stomach. On challenge with H. pylori, these mice develop an accelerated inflammatory response leading to atrophic gastritis. In our model, MAIT cells have a pathogenic rather than protective effect. We are working to understand their role with a view to therapeutic intervention.
Date:
21 July 2015, 13:00
Venue:
Medawar Building, off South Parks Road OX1 3SY
Venue Details:
Seminar Room 30, Call 281231on arrival for entry
Speaker:
Criselle D'Souza (McCluskey laboratory Department of Microbiology and Immunology The Peter Doherty Institute for Infection and Immunity The University of Melbourne)
Organising department:
Nuffield Department of Clinical Medicine
Organiser:
Chris Willberg (NDM Experimental Medicine)
Part of:
Peter Medawar Building Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Chris Willberg
