CANCELLED - To Be Rescheduled. The subthalamic nucleus and self-control: evidence from neuromodulation
The subthalamic nucleus (STN) is a critical structure underlying self-control. It is implicated in inhibitory processes and its position within the indirect pathway and receiving hyperdirect cortical projections emphasizes its role as a nexus for integration. Clinically, the STN is a target for deep brain stimulation for Parkinson’s disease and obsessive-compulsive disorder (OCD) with preclinical evidence suggesting a role for addictions. Here I will describe a body of research in OCD patients with deep brain stimulation targeting the associative-limbic STN focusing on subtypes of decisional impulsivity. I argue that these disparate findings can be linked through the effect of STN stimulation on decreasing decision thresholds, and on valence and affect. I further elaborate on a novel transcranial magnetic stimulation application using paired associative stimulation demonstrating the capacity to modulate response inhibition via cortical-STN pathways. Together, these findings expand on STN function and self-control and highlight its translational and therapeutic relevance to psychiatric disorders.
Date: 23 January 2018, 9:30 (Tuesday, 2nd week, Hilary 2018)
Venue: Warneford Hospital, Headington OX3 7JX
Venue Details: Seminar Room, University Department of Psychiatry
Speaker: Dr Valerie Voon (Senior Research Associate, Department of Psychiatry, University of Cambridge)
Organising department: Department of Psychiatry
Organiser: Tracy Lindsey
Part of: Psychiatry Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Tracy Lindsey