The Evolutionary Genomics of Staphylococcus aureus Infections
Free nibbles and discussion between early career researchers and the speaker at Oxford University Club, 11 Mansfield Road, Oxford, OX1 3SZ from 2.30pm
Like other major bacterial pathogens, S. aureus asymptomatically colonizes the human body far more frequently than it causes severe infections. This raises the question of what are the evolutionary and genetic differences between infection and asymptomatic colonization? To address this question we have sequenced and analysed S. aureus genomes to chart evolution within hundreds of healthy and infected patients, and to discover genetic differences associated with bacteria infecting and colonizing thousands of unrelated cases and controls. These studies reveal surprising differences in the genetic basis of different types of infection, and reveal signatures of bacterial adaptation within the human body to selection pressures that are as yet incompletely understood.
Date: 5 February 2018, 13:00 (Monday, 4th week, Hilary 2018)
Venue: University Museum of Natural History, Parks Road OX1 3PW
Venue Details: Lecture Theatre
Speaker: Associate Professor Daniel Wilson (Nuffield Department of Medicine)
Organising department: Department of Zoology
Organisers: Dr Roberto Salguero-Gomez (University of Oxford), Professor Aziz Aboobaker (Dept Zoology, University of Oxford)
Organiser contact email address: administrator.pa@zoo.ox.ac.uk
Host: Associate Professor Craig MacLean (University of Oxford)
Part of: the zoology lectures 2017/18
Topics: Epidemiology, Evolution, Microbiology, Genetics
Booking required?: Not required
Audience: Public
Editor: Kirsty Jackson