OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Cytotoxic T lymphocytes (CTLs) are critical for defense against intracellular pathogens and cancer. CTL differentiation begins when a naïve CD8+ T cell recognizes a peptide-MHC ligand complex through its T cell receptor (TCR), triggering a cascade of activation events. The interaction of the TCR with a particular peptide-MHC complex is exquisitely sensitive, such that single amino acid changes in the presented peptide can dramatically alter the activation of responding T cells. Multiple mechanisms have been proposed to underlie this phenomenon, but these cannot be distinguished through snapshot measurements in bulk cellular populations. In this talk, I will describe how we address this using multidimensional measurements (single-cell RNAseq and mass cytometry) of molecular activation events in individual cells over time.
