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A rate-limiting process: T cell activation from a single-cell perspective
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJYocuGupzgpGtQi_Iz7Yd_vTyQvP8eeUbAc
Cytotoxic T lymphocytes (CTLs) are critical for defense against intracellular pathogens and cancer. CTL differentiation begins when a naïve CD8+ T cell recognizes a peptide-MHC ligand complex through its T cell receptor (TCR), triggering a cascade of activation events. The interaction of the TCR with a particular peptide-MHC complex is exquisitely sensitive, such that single amino acid changes in the presented peptide can dramatically alter the activation of responding T cells. Multiple mechanisms have been proposed to underlie this phenomenon, but these cannot be distinguished through snapshot measurements in bulk cellular populations. In this talk, I will describe how we address this using multidimensional measurements (single-cell RNAseq and mass cytometry) of molecular activation events in individual cells over time.
Date:
7 September 2020, 14:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held using Zoom. Please register here: https://zoom.us/meeting/register/tJYocuGupzgpGtQi_Iz7Yd_vTyQvP8eeUbAc
Speaker:
Dr Arianne Richard (University of Cambridge)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organiser:
Jennifer Pope (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Professor Mike Dustin (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://zoom.us/meeting/register/tJYocuGupzgpGtQi_Iz7Yd_vTyQvP8eeUbAc
Audience:
Members of the University only
Editor:
Jennifer Pope
