OxTalks is Changing
OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
"Cell shape formation controlled by cytoskeleton"
Neurons are highly polarized cells whose shape is controlled by cytoskeleton networks. The formation of neuronal protrusions such as dendrites and axons is mediated by the dynamic nature of microtubules, and it is the basis of neuronal development. Particularly at axon branches, signaling processes trigger actin re-formation leading to the recruitment of microtubules to reinforce the branching site; however, little is known about this remodeling mechanism.
Combining the interdisciplinary methods of cryo-EM, biophysics, and cell biology, we focus on elucidating the mechanism of neuronal cell shape formation and accompanying cytoskeleton remodeling.
We will present our recent discovery of a novel factor SSNA1, promoting axon branch formation. To understand the underlying mechanism of branch promotion, we have characterized the interaction of the protein with tubulin and reconstituted its microtubule nucleation process in vitro. Moreover, cryo-EM revealed the surprising observation that SSNA1 facilitates direct microtubule branching. Mutagenesis experiments in primary neurons correlate the molecular remodeling activity with the formation of axon branches.
Date:
25 January 2019, 11:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting rooms A & B
Speaker:
Dr Naoko Mizuno (Max Planck Institue of Biochemistry)
Organiser:
Agata Krupa (Wellcome Centre for Human Genetics, University of Oxford)
Host:
Prof David Stuart (University of Oxford)
Part of:
Strubi seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Agata Krupa
