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Seminar by Prof Peter Lee 'Imaging human organs from the cellular to whole organ scale using Hierarchical Phase-Contrast Tomography (HiP-CT)'
This seminar will be held virtually via Zoom. This seminar is open only to members of Oxford University, register with a valid Oxford University email address at https://medsci.zoom.us/meeting/register/tJAlfuqrqj0tEtGo49eNuuK4t-WPh9iDDI7R
Hierarchical Phase-Contrast Tomography (HiP-CT) is a new x-ray tomography technique that spans a previously poorly explored scale in our understanding of human anatomy, the micron to whole intact organ scale. HiP-CT is a propagation-based phase-contrast x-ray imaging technique utilises the higher energies, higher beam coherence and small source size enabled by the Extremely Brilliant Source upgrade of the European Synchrotron Radiation Facility (ESRF-EBS). Using HiP-CT we are developing a ‘Human Organ Atlas’ that bridges the traditional imaging scales of histology (using optical and electron microscopy images cells and other structures with sub-micron accuracy but only on small biopsies of tissue from an organ) to clinical CT and MRI scans (which can image whole organs, but with a resolution only down to just below a millimetre). HiP-CT bridges these scales in 3D, imaging intact organs with ca. 20 micron voxels, and locally down to the micron scale. We hope this open access Atlas, enabled by the ESRF-EBS, will act as a reference to provide new insights into our biological makeup in health and disease. See mecheng.ucl.ac.uk/hip-ct for more details, a list of our publications (e.g. bit.ly/HiP-CT-paper ) and videos seeing inside our organs with near micron resolution (bit.ly/HiP-CT-videos).
The HiP-CT technique was developed to image complete human organs, including those damaged by SARS-CoV-2 infection, through an international collaboration of imaging scientists at University College London and ESRF, working with Clinical scientists treating COVID-19 patients in Hannover, Mainz, Heidelberg and Grenoble, to help understand the disease.
Date:
7 March 2022, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held virtually via Zoom. This seminar is open only to members of Oxford University, register with a valid Oxford University email address at https://medsci.zoom.us/meeting/register/tJAlfuqrqj0tEtGo49eNuuK4t-WPh9iDDI7R
Speaker:
Prof Peter Lee (UCL)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
ellen.mobbs@kennedy.ox.ac.uk
Host:
Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://medsci.zoom.us/meeting/register/tJAlfuqrqj0tEtGo49eNuuK4t-WPh9iDDI7R
Audience:
Members of the University only
Editors:
Elizabeth Thompson,
Ellen Mobbs
