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Do the shapes of tumour cell nuclei influence their infiltration?
The question can be formulated as a statistical hypothesis asserting that the distribution of the shapes of closed curves representing outlines of cell nuclei in a spatial domain is independent of the distribution of their locations. The key challenge in developing a procedure to test the hypothesis from a sample of spatially indexed curves (e.g. from an image) lies in how symmetries in the data are accounted for: shape of a curve is a property that is invariant to similarity transformations and reparameterization, and the shape space is thus an infinite-dimensional quotient space. Starting with a convenient geometry for the shape space developed over the last few years, I will discuss dependence measures and their estimates for spatial point processes with shape-valued marks, and demonstrate their use in testing for spatial independence of marks in a breast cancer application.
Date:
2 May 2025, 11:00
Venue:
Mathematical Institute, Woodstock Road OX2 6GG
Venue Details:
L4
Speaker:
Professor Kharthik Bharath (School of Mathematics, University of Nottingham)
Organising department:
Mathematical Institute
Organiser contact email address:
jolliffe@maths.ox.ac.uk
Host:
Prof Helen Byrne (University of Oxford)
Part of:
Mathematical Biology and Ecology
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sara Jolliffe
