Hyperglycemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis
Accumulating evidence shows how diverse physiological functions, such as metabolism, immunity, tissue homeostasis, and hematopoiesis, are intricately and profoundly intertwined at multiple levels. This presentation will consider evidence from a rapidly expanding field of immunometabolism, highlighting how cells that are relevant to processes at play in determining vascular health and disease can be programmed by changes in their metabolic environment. It will focus on how such changes can be imprinted or trained, particularly through epigenetic modifications, such that adaptations driven by metabolic signals can cause persistent changes in cell function, even after the original stimulus has been corrected or removed. Recognition of these processes and elucidation of the mechanisms underlying them stand to have far-reaching implications for the diagnosis and treatment of diabetes and related metabolic states.
Date: 3 November 2022, 17:30 (Thursday, 4th week, Michaelmas 2022)
Venue: St Catherine's College, Manor Road OX1 3UJ
Venue Details: JCR Lecture Theatre
Speaker: Professor Robin Choudhury (University of Oxford)
Organiser: Oxford University Scientific Society (University of Oxford)
Organiser contact email address: scientific.society@studentclubs.ox.ac.uk
Booking required?: Not required
Audience: Public
Editor: Lorenzo Piersante