OxTalks will soon move to the new Halo platform and will become 'Oxford Events.' There will be a need for an OxTalks freeze. This was previously planned for Friday 14th November – a new date will be shared as soon as it is available (full details will be available on the Staff Gateway).
In the meantime, the OxTalks site will remain active and events will continue to be published.
If staff have any questions about the Oxford Events launch, please contact halo@digital.ox.ac.uk
Joining genetic data with phenotype data creates an opportunity to put genetic information into context with observable characteristics. Both genetic and environmental sources can influence phenotypic variation in a given population. An important part of drawing conclusions about the genetic contribution is specifying the phenotype and preparing the data in a suitable manner. That process involves various challenges since phenotypes often vary over time and are susceptible to external influences. In addition, measurement errors can add noise and/or bias to the data.
I will discuss the process of specifying categorical and quantitative phenotypes and preparing the phenotype data for genetic studies. Topics include inverse normal transformation of quantitative phenotypes, adjusting (or not) for individual characteristics, clinical diagnoses vs research definitions, circumstantial datasets vs generated datasets and genotype-to-phenotype studies.
