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Seminar by Dr Tom Cupedo "Stromal – Immune interactions in the multiple myeloma bone marrow"
This seminar will be held in the Kennedy Lecture Theatre with the option to join via Zoom at https://medsci.zoom.us/meeting/register/tJ0kdO-gqTsjG9GKjVn2TQyOSFX5bDk4Vens
Multiple myeloma (MM) is characterized by accumulation of malignant plasma cells in the bone marrow, where tumor cells are in close contact with stromal fibroblasts. Using single cell RNA-sequencing we generated transcriptional maps of MM cells and their stromal and immune microenvironments. This revealed the presence of inflammatory stromal fibroblasts and bone marrow inflammation. I will discuss the identity of the MM stromal cells, their possible impact on MM disease progression and the interactions between inflammatory stromal cells and innate immune cells leading to a pro-tumor bone marrow environment.
Date:
12 May 2022, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held in the Kennedy Lecture Theatre with the option to join via Zoom at https://medsci.zoom.us/meeting/register/tJ0kdO-gqTsjG9GKjVn2TQyOSFX5bDk4Vens
Speaker:
Dr Tom Cupedo (Erasmus MC, Netherlands)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Ellen Mobbs (Kennedy Institute of Rheumatology),
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
ellen.mobbs@kennedy.ox.ac.uk
Host:
Prof Mark Coles (Kennedy Institute of Rheumatology )
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://medsci.zoom.us/meeting/register/tJ0kdO-gqTsjG9GKjVn2TQyOSFX5bDk4Vens
Audience:
Members of the University only
Editors:
Elizabeth Thompson,
Ellen Mobbs
