The last 10 years have seen the emergence of predictive models based on genetics which quantify an individual’s genetic predisposition for a specific trait or disease. In this talk, I will present our latest research in the construction, cataloging and translation of polygenic scores with a focus on common disease risk. I will also cover examples of integrating polygenic scores with multi-omics data to enhance clinical risk prediction models and to understand putative molecular mediators of polygenic disease.