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Tissue Engineering: From Cytoneme Contact To Theraputic Impact
This seminar is open to members of the University of Oxford only. Please register with your University of Oxford email to ensure a successful registration. Registration is at: https://medsci.zoom.us/meeting/register/tJIsduCorz8qGtGMab43w_43jXsijjZP85ii
Wnt signalling is an ancient pathway that accompanied the evolution of metazoans and plays major roles in developmental processes including the function of stem cells and tissue patterning.
Shukry pioneered the technology of immobilising Wnt proteins to synthetic surfaces. He has shown that localised Wnts can maintain a variety of stem cell types and control oriented asymmetric cell division. His lab studies how the stem cells interact with their niche to recruit localised Wnts and initiate tissue formation. Specifically, they investigate mechanisms of breaking cellular symmetry, cell sorting and self-organisation during embryogenesis and adult skeletal tissue formation. Using this knowledge, they engineered a 3D human osteogenic tissue model (WIOTM) that maintains human skeletal stem cells and a cascade of osteogenic differentiation. Recently, they engineered novel Wnt- and WIOTM- bandages that can promote repair in bone defects that cannot heal by themselves. Importantly, they also generated humanized bone in mice. These technologies can be adapted to other tissues for repair, high-throughput screening applications and disease modelling.
Date:
5 July 2021, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
This seminar will be held using Zoom. Please register here: https://medsci.zoom.us/meeting/register/tJIsduCorz8qGtGMab43w_43jXsijjZP85ii
Speaker:
Dr Shukry Habib (King's College London)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Dr Jelena Bezbradica (The Kennedy Institute of Rheumatology),
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Professor Tonia Vincent (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Required
Booking url:
https://medsci.zoom.us/meeting/register/tJIsduCorz8qGtGMab43w_43jXsijjZP85ii
Audience:
Members of the University only
Editor:
Jennifer Pope
