Dissecting Reacitve Oxygen Species Biology in Health and Disease
In-person only
I will discuss our work on the phagocyte NADPH oxdase (NOX2). This crucial multi-subunit complex generates reactive oxygen species (ROS) to kill pathogens but is also essential for immune regulation. We have described EROS as a crucial chaperone for NOX2 assembly and inflammasome signalling. I will present some published work and unpublished findings on EROS’s role in adaptive immunity and a novel regulator of reactive oxygen species generation. I will then describe how investigating the Duox2-Duoxa2 system in ROS generation led us to discover an essential role of thyroid hormone in NK cell biology. This is a collaboration with Alice Denton (Imperial College).
Date: 23 June 2025, 12:00
Venue: Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details: Kennedy Lecture Theatre
Speaker: Prof David Thomas (University of Cambridge)
Organising department: Kennedy Institute of Rheumatology
Organiser: Magdalena Gross
Host: Dr Tal Arnon (Kennedy Institute of Rheumatology)
Part of: Kennedy Institute Seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Magdalena Gross