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Dissecting Reacitve Oxygen Species Biology in Health and Disease
In-person only
I will discuss our work on the phagocyte NADPH oxdase (NOX2). This crucial multi-subunit complex generates reactive oxygen species (ROS) to kill pathogens but is also essential for immune regulation. We have described EROS as a crucial chaperone for NOX2 assembly and inflammasome signalling. I will present some published work and unpublished findings on EROS’s role in adaptive immunity and a novel regulator of reactive oxygen species generation. I will then describe how investigating the Duox2-Duoxa2 system in ROS generation led us to discover an essential role of thyroid hormone in NK cell biology. This is a collaboration with Alice Denton (Imperial College).
Date:
23 June 2025, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Kennedy Lecture Theatre
Speaker:
Prof David Thomas (University of Cambridge)
Organising department:
Kennedy Institute of Rheumatology
Organiser:
Magdalena Gross
Host:
Dr Tal Arnon (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Magdalena Gross
