Neurotransmitter receptor gradients: gateways for neuromodulation of cortex-wide dynamics during cognition
Recent advances in neuroanatomy and physiology make it possible to probe whole-brain mechanisms of cognition and behavior. However, as yet, few models in computational neuroscience have tackled the mechanisms underlying highly distributed neural activity during cognitive tasks. In this talk I will describe our anatomy-led approach to developing cortex-wide models of neural dynamics during cognitive tasks and our recent anatomical findings of gradients of neurotransmitter receptors in the cortex. I will highlight our investigations into how inputs from neuromodulatory systems may shift the cortical dynamical landscape, affecting cell-type specific interactions, and how this may confer flexibility on distributed cognitive functions such as conscious perception and working memory.
Date:
1 May 2025, 15:00
Venue:
Sherrington Building, off Parks Road OX1 3PT
Venue Details:
Florence Buchanan Lecture Theatre
Speaker:
Dr Sean Froudist-Walsh (University of Bristol)
Organising department:
Medical Sciences Division
Organisers:
Dr Jascha Achterberg (University of Oxford),
Dr Rui Ponte Costa (University of Oxford)
Organiser contact email address:
jascha.achterberg@dpag.ox.ac.uk
Host:
Dr Rui Ponte Costa (University of Oxford)
Part of:
Oxford Neurotheory Forum
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Jascha Achterberg
