Cryomicroscopy of cellular and viral architecture
I will describe research in two areas of interest to my laboratoy: (1) electron cryotomography and three-dimensional reconstruction of the thin edge of frozen-hydrated cells to understand cytoskeletal architecture and to understanding the packaging of von Willebrand factor (VWF) in rod-shape granules in endothelial cells called Weibel-Palade bodies (WPBs). (2) three-dimensional reconstruction of lipid-enveloped influenza viruses to understand virus assembly and entry into cells during infection. Lastly, I will discuss methods for improving cryomicroscopy images from the molecular to the cellular scale.
Date: 12 June 2015, 11:00 (Friday, 7th week, Trinity 2015)
Venue: Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details: Meeting Rooms A & B
Speaker: Prof Peter Rosenthal (The Francis Crick Institute )
Organising department: Wellcome Trust Centre for Human Genetics
Organiser: Eleanor Martin (Wellcome Trust Centre for Human Genetics)
Organiser contact email address:
Hosts: Prof E.Yvonne Jones (University of Oxford), Prof David Stuart (University of Oxford)
Part of: Strubi seminars
Booking required?: Not required
Audience: Members of the University only
Editor: Eleanor Martin