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Cryomicroscopy of cellular and viral architecture
I will describe research in two areas of interest to my laboratoy: (1) electron cryotomography and three-dimensional reconstruction of the thin edge of frozen-hydrated cells to understand cytoskeletal architecture and to understanding the packaging of von Willebrand factor (VWF) in rod-shape granules in endothelial cells called Weibel-Palade bodies (WPBs). (2) three-dimensional reconstruction of lipid-enveloped influenza viruses to understand virus assembly and entry into cells during infection. Lastly, I will discuss methods for improving cryomicroscopy images from the molecular to the cellular scale.
Date:
12 June 2015, 11:00
Venue:
Wellcome Trust Centre for Human Genetics, Headington OX3 7BN
Venue Details:
Meeting Rooms A & B
Speaker:
Prof Peter Rosenthal (The Francis Crick Institute )
Organising department:
Wellcome Trust Centre for Human Genetics
Organiser:
Eleanor Martin (Wellcome Trust Centre for Human Genetics)
Organiser contact email address:
jones-pa@strubi.ox.ac.uk
Hosts:
Prof E.Yvonne Jones (University of Oxford),
Prof David Stuart (University of Oxford)
Part of:
Strubi seminars
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Eleanor Martin
