Mechanisms Driving the Rapid Evolution of Genomes
Annual Jordan Translational Medicine Lecture - this is an in-person event only
David Pellman’s laboratory investigates how errors in cell division lead to catastrophic mutational events, genome instability, and cancer. His group has uncovered mechanisms linking nuclear architecture to chromothripsis and other major genomic rearrangements, revealing how abnormal nuclear structures contribute to tumour evolution. Their recent work explores how nuclear atypia can cause heritable changes in chromatin organisation and gene expression, advancing our understanding of genome instability in human disease.
Date: 6 November 2025, 13:00
Venue: MRC Weatherall Institute of Molecular Medicine, Headington OX3 9DS
Venue Details: WIMM Seminar Room
Speaker: Professor David Pellman (Harvard Medical School)
Organising department: MRC Weatherall Institute of Molecular Medicine
Organiser: Beatriz Hirt-Font (University of Oxford, MRC Weatherall Institute of Molecular Medicine)
Organiser contact email address: beatriz.hirt-font@imm.ox.ac.uk
Host: Prof Ketan Patel (University of Oxford)
Part of: Jordan Translational Medicine Lecture Series
Booking required?: Required
Booking email: beatriz.hirt-font@imm.ox.ac.uk
Audience: Members of the University only
Editors: Fiona Lambert, Beatriz Hirt-Font, Kay Levendale