OxTalks is Changing
On 28th November OxTalks will move to the new Halo platform and will become 'Oxford Events' (full details are available on the Staff Gateway).
There will be an OxTalks freeze beginning on Friday 14th November. This means you will need to publish any of your known events to OxTalks by then as there will be no facility to publish or edit events in that fortnight. During the freeze, all events will be migrated to the new Oxford Events site. It will still be possible to view events on OxTalks during this time.
If you have any questions, please contact halo@digital.ox.ac.uk
'Allosteric mechanisms of cellular stress response'
The integrated stress response (ISR) enables cells to survive a variety of acute stresses, but chronic activation of the ISR drives disease via incompletely understood metabolic mechanisms. ISR signaling downregulates translation and activates expression of stress-responsive factors that promote return to homeostasis and is initiated by inhibition of the decameric guanine nucleotide exchange factor eIF2B. I will present on the discovery of eIF2B’s allosteric mechanism: using hydrogen–deuterium exchange–mass spectrometry and cryo-electron microscopy, we identified a central α-helix whose orientation allosterically coordinates eIF2B conformation and assembly. Biochemical and cellular signaling assays show that this ‘switch-helix’ controls eIF2B activity and signaling. In sum, the switch-helix acts as a fulcrum of eIF2B conformational regulation and is a highly conserved actuator of ISR signal transduction. To conclude the talk, I will discuss future directions leveraging our understanding of the eIF2B Switch-Helix to gain rational control over signaling in cultured cells, opening up the ability to define precise mechanisms of metabolic mechanisms of chronic stress-induced disease.
Date:
25 June 2024, 11:30
Venue:
Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details:
Seminar Room 1, Room 20-026
Speaker:
Dr. Rosalie Lawrence (Jane Coffin Childs Postdoctoral Fellow, Peter Walter Lab, UCSF)
Organising department:
Department of Biochemistry
Organiser:
Sarah-jane Scard (Department of Biochemistry)
Organiser contact email address:
sarah-jane.scard@bioch.ox.ac.uk
Host:
Professor Simon Newstead (University of Oxford,)
Part of:
Special Seminar
Booking required?:
Not required
Audience:
Members of the University only
Editor:
Sarah-Jane Scard
