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Function and mechanisms of the ChAHP-family chromatin remodeler complexes
The ChAHP complex is an essential genome regulator that integrates a transcription factor, a chromatin remodeler and heterochromatin proteins into a single functional unit. I will present our recent discovery of its role in repressing transposons and the molecular mechanisms underpinning this function. Our identification of the paralogous ChAHP2 complex and its distinct properties establishes this protein family as a conserved, vertebrate-specific component of the retrotransposon control machinery.
Date:
13 November 2025, 11:00
Venue:
Dorothy Crowfoot Hodgkin Building, off South Parks Road OX1 3QU
Venue Details:
Seminar Room 2, Room 20-138
Speaker:
Dr Josip Ahel (Friedrich Miescher Institute for Biomedical Research, Basel)
Organising department:
Department of Biochemistry
Organiser:
Dr James Holder (Department of Biochemistry, University of Oxford)
Organiser contact email address:
james.holder@bioch.ox.ac.uk
Hosts:
Dr James Holder (Department of Biochemistry, University of Oxford),
Professor Francis Barr (Department of Biochemistry, University of Oxford )
Part of:
CBDG
Booking required?:
Not required
Audience:
Members of the University only
Editors:
Jeremy Rowntree,
Jessica Barnes
