OxTalks is Changing
Oxford Events, the new replacement for OxTalks, will launch on 16th March. From now until the launch of Oxford Events, new events cannot be published or edited on OxTalks while all existing records are migrated to the new platform. The existing OxTalks site will remain available to view during this period.
From 16th, Oxford Events will launch on a new website: events.ox.ac.uk, and event submissions will resume. You will need a Halo login to submit events. Full details are available on the Staff Gateway.
DNA Sensing controls immune balance in chronic conditions
Chronic inflammation generates damage-associated molecular patterns (DAMPs) such as DNA that impact immune responses. DNA is sensed to activate the Stimulator of Interferon Genes (STING) adaptor which may stimulate or suppress immunity. In some cancer models DNA suppresses anti-tumour immunity to promote tumour growth by inducing indoleamine 2,3 dioxygenase (IDO). STING agonists enhance anti-tumour immunity but fail to control tumour growth unless immune checkpoints are also disrupted. DNA sensing pathways can also be exploited to attenuate autoimmunity in several models of clinical autoimmune syndromes. Hence, STING agonists can be used to manipulate immune balance in a range of chronic conditions.
Date:
10 February 2020, 12:00
Venue:
Kennedy Institute of Rheumatology, Headington OX3 7FY
Venue Details:
Bernard Sunley Lecture Theatre
Speaker:
Professor Andrew Mellor (Newcastle University)
Organising department:
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS)
Organisers:
Jennifer Pope (Kennedy Institute of Rheumatology),
Professor Irina Udalova (Kennedy Institute of Rheumatology)
Organiser contact email address:
jennifer.pope@kennedy.ox.ac.uk
Host:
Dr Richard Williams (Kennedy Institute of Rheumatology)
Part of:
Kennedy Institute Seminars
Booking required?:
Not required
Audience:
Public
Editor:
Jennifer Pope
